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Ho-Mahler N, Turner B, Eaddy M, Hanke ML, Nelson WW—Open Access Rheumatology: Research and Reviews, 2020
Disclosure statement: Funding to support this study was provided by Mallinckrodt Pharmaceuticals.
To better understand the practice patterns and outcomes of Acthar Gel in patients with RA, SLE, or DM/PM.
Patients in the retrospective study had a mean age of >49 years (mean age range: 49.3 years to 54.8 years) and were mostly female (78% [RA], 97% [SLE], and 100% [DM/PM]).
ACR=American College of Rheumatology.
Most commonly reported comorbidities in patients with RA, SLE, and DM/PM (N=92)
Most patients had been treated with multiple prior therapies, suggesting refractory disease1
Prior therapies included glucocorticoids, immunosuppressants, and biologic and nonbiologic DMARDs
DMARDs=disease-modifying antirheumatic drugs.
Mean duration of Acthar Gel treatment was 4.8 months to 6.8 months1
Most common starting dose and frequency of Acthar Gel1,2
Most common reasons for initiating treatment with Acthar Gel for patients with data1
Patients who had rating of "improved"1
Rating of "improved" among the 57 patients with data on physician's impression of change with Acthar Gel1
Clinical outcomes may not be solely attributable to Acthar Gel.
Time to best impression of change (mean)1*
Time to best impression of change (mean)* among the 57 patients with data on physician's impression of change with Acthar Gel1
SD=standard deviation.
*Mean time plus SD was 3.4±2.5 months for RA, 4.3±2.7 months for SLE, and 3.4±1.6 months for DM/PM.
SAEs were reported in:
AEs were reported in:
Patients (N=92) who discontinued Acthar Gel
Most common reasons for discontinuation of Acthar Gel among the 35 patients with data
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Acthar® Gel is indicated for:
Contraindications
Acthar is contraindicated:
Warnings and Precautions
Adverse Reactions
Pregnancy
Please see full Prescribing Information for additional Important Safety Information.
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