Dosing and Administration

Acthar is a highly purified sterile preparation of adrenocorticotropic hormone in 16% gelatin to provide a prolonged release after subcutaneous or intramuscular injection.

Acthar offers flexible dosing for your patients:

  • Acthar is a self-administered injection, which gives patients the flexibility to take it at home or wherever it is best for them
  • Dosage and frequency of administration should be individualized according to the medical condition, disease severity, and initial response of the patient1

Dosing options according to the label1

Injection Subcutaneous or intramuscular
Dose 40-80 units
Schedule Every 1–3 days

SC Injection Training Video

Step-by-step instructions on how to inject Acthar subcutaneously.

Step-by-step instructions on how to inject Acthar subcutaneously.1:22

Watch Spanish version.

IM Injection Training Video

Step-by-step instructions on how to inject Acthar intramuscularly.

Step-by-step instructions on how to inject Acthar subcutaneously.1:19

Watch Spanish version.


IMPORTANT SAFETY INFORMATION

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Contraindications

  • Acthar should never be administered intravenously
  • Administration of live or live attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of Acthar
  • Acthar is contraindicated where congenital infections are suspected in infants
  • Acthar is contraindicated in patients with scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, history of or the presence of a peptic ulcer, congestive heart failure, uncontrolled hypertension, primary adrenocortical insufficiency, adrenocortical hyperfunction or sensitivity to proteins of porcine origins

INDICATIONS

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H.P. Acthar® Gel (repository corticotropin injection) is an adrenocorticotropic hormone (ACTH) analogue used for:

  • Treatment during an exacerbation or as maintenance therapy in selected cases of systemic dermatomyositis (polymyositis)
  • Treatment during an exacerbation or as maintenance therapy in selected cases of systemic lupus erythematosus
  • The treatment of symptomatic sarcoidosis
  • Adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)